Effect of Yuxianling granule on MFS in rats kindled with pentylenetetrazol

Objective To observe the effect of Yuxianling granule(YXLG) on the MFS in epileptic model rats caused by PTZ.Methods 70 SD rats,except for 10 rats were selected randomly as the blank control group,were modeled by pentylenetetrazol(PTZ) and divided randomly into three groups,YXLG group,sodium valproate group and model group.MFS was observed with Timm and the effect of YXLG on MFS was studied.Results Compared the model group,the difference of with blank group,the MFS of IML was not significant(P0.05) and the differences of the dyed-black points number and the dyed-black points'area density of MFS in CA3 of hippocampal slice were significant statistical significant(P0.01);Comprehensive routine biopsy results suggested that epilepsy could led to death of hippocampal neurons,and caused MFS.Compared YXLG group with model group,the differences of dyed-black points number and the dyed -black points'area density of MFS in CA3 were significant statistical significant(P0.01).Conclusions ① There exists the state of MFS in hippocampal slice.② YXLG can reduce the numbers and positive of hippocampal MFS,which suggests that YXLG can protect the hippocampal neurons.and inhibit MFS.