Piperacillin-Tazobactam-induced Adverse Drug Events in Pediatric Patients on Outpatient Parenteral Antimicrobial Therapy.
2017
We report a significantly higher occurrence of adverse events associated with prolonged courses of piperacillin–tazobactam compared with other antibacterial agents used for pediatric outpatient parenteral antimicrobial therapy. These adverse events were characterized by a constellation of clinical findings including fever, hematologic abnormalities and transaminitis. Adverse events related to piperacillin–tazobactam should be considered in patients who develop a febrile illness associated with a prolonged course of therapy.
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