Cold tolerance of UCP1-ablated mice: a skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects.

Irina G. Shabalina,Joris Hoeks,Tatiana V. Kramarova,Patrick Schrauwen,Barbara Cannon,Jan Nedergaard

Cold tolerance of UCP1-ablated mice: a skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects.

2010

Irina G. Shabalina
Joris Hoeks
Tatiana V. Kramarova
Patrick Schrauwen
Barbara Cannon
Jan Nedergaard

Mice lacking the thermogenic mitochondrial membrane protein UCP1 (uncoupling protein 1) - and thus all heat production from brown adipose tissue - can still adapt to a cold environment (4 degrees C ...

Keywords:

UCP3
Mitochondrial Membrane Protein
Brown adipose tissue
Skeletal muscle
Uncoupling protein
Thermogenin
Thermogenesis
Biochemistry
Biology
Mitochondrion
cold acclimation
lipid oxidation

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