Spontaneous Immunity Against the Receptor Tyrosine Kinase ROR1 in Patients with Chronic Lymphocytic Leukemia

Mohammad Hojjat-Farsangi,Mahmood Jeddi-Tehrani,Amir Hossein Daneshmanesh,Fariba Mozaffari,Ali Moshfegh,Lotta Hansson,Seyed Mohsen Razavi,Ramazan Ali Sharifian,Hodjattallah Rabbani,Anders Österborg,Håkan Mellstedt,Fazel Shokri

Spontaneous Immunity Against the Receptor Tyrosine Kinase ROR1 in Patients with Chronic Lymphocytic Leukemia

2015

Mohammad Hojjat-Farsangi
Mahmood Jeddi-Tehrani
Amir Hossein Daneshmanesh
Fariba Mozaffari
Ali Moshfegh
Lotta Hansson
Seyed Mohsen Razavi
Ramazan Ali Sharifian
Hodjattallah Rabbani
Anders Österborg
Håkan Mellstedt
Fazel Shokri

Background ROR1 is a receptor tyrosine kinase expressed in chronic lymphocytic leukemia (CLL) and several other malignancies but absent in most adult normal tissues. ROR1 is considered an onco-fetal antigen. In the present study we analysed spontaneous humoral and cellular immunity against ROR1 in CLL patients.

Keywords:

Antibody
Chronic lymphocytic leukemia
Immune system
ROR1
Immunology
Receptor tyrosine kinase-like orphan receptor
Receptor tyrosine kinase
Immunoglobulin G
Cancer research
CD135
Biology
cellular immunity

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