PS1-29: Preparing for Genetics Research on Serious Skin Rash in the HMO Research Network

Background/Aims Stevens-Johnson syndrome (SJS) and toxic epidermal necrolyssis (TEN) are life-threatening widespread serious skin rashes (SSR), often accompanied by extensive epidermal detachment and/or mucous membrane involvement. Recent genetic studies have shown a strong link in Han Chinese between HLA-B*1502 and risk for SJS with use of Carbamazepine; however, more research is needed to identify similar markers among other ethnic groups. With support from The International Serious Adverse Event Consortium, we evaluated the potential for using electronic clinical and administrative data from Kaiser Permanente Hawaii and Kaiser Permanente Georgia to identify provisional SSR cases.