Autophagy as a Pathogenetic Link and a Target for Therapy of Musculoskeletal System Diseases
2021
Autophagy is an evolutionarily conserved process of degradation
of intracellular structures by lysosomal enzymes in specialized
compartments such as autophagolysosomes plays a role in many processes,
such as differentiation, maintenance of energy homeostasis, and
protection of cells in the presence of destructive changes. Autophagy
is of particular importance for the functioning of skeletal and
cardiac muscles, namely, to maintain the structural and physiological
integrity of the sarcomere during muscle contraction, as well as
for pathological changes in the muscle fiber. Activation of the
autophagy process occurs in response to a variety of stressful stimuli,
such as muscle damage during intense exercise, resulting in tissue
repair, including through the activation of satellite cells. In
this review, autophagy is considered as a protective process, in
which several types are distinguished, differing in their mechanisms.
The review will cover the molecular basis of the autophagy process,
its role in the vital activity and functioning of cells, as well
as the therapeutic potential of autophagy activators in the treatment
of severe human diseases associated with disorders of skeletal and
cardiac muscles. Special attention will be paid to the description
of pharmacological drugs that can enhance the activity of autophagy,
as well as the mechanisms of their action.
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