The role of Sestrins in the regulation of the aging process.

Abstract Sestrins (Sesns) represent a highly conserved family of stress-inducing proteins that are involved in antioxidant and autophagy regulatory functions. They are very important mediators as they can protect the cells under a variety of noxious stimulating conditions. However, the functions of Sesns in aging has not yet been fully understood. Here, we summarize the roles of Sesns in the aging process. A series of studies have shown that Sesns are highly involved in the aging process by regulating the nutritional perception, metabolic homeostasis, immunity, autophagy, lifespan and health span. The details of how Sesns act on them will be described in this review. Due to the conservation of their function during evolution, Sesns may be used as novel targets for aging intervention and also provide new strategies for anti-aging treatment.