Elevated serum anti-I2 and anti-OmpW antibody levels in children with IBD

OmpW, I2, and perinuclear anti-neutrophil cytoplasmic antibodies detected 83% of UC cases. Conclusions: Among children with IBD, strong serological responses to microbial antigens can be found, suggesting that P fluorescens and B caccae antigens have a potential role in the microbiology and immunology of the disease. Furthermore, serologic reactivity to the set of antigens studied here seems to be applicable in the initial differential diagnosis of children with CD and UC.