Ainsliadimer A selectively inhibits IKKα/β by covalently binding a conserved cysteine.
2015
IKK is a key inducer of NF-κB, and has been targeted by several small molecule drugs. Here the authors show that a natural product from a Chinese medical herb inhibits NF-κB via covalent binding to a unique conserved region of IKK, and efficiently inhibits tumour growth and sepsis in mice.
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