Anti-tumour Secondary Metabolites from the Coral-derived Bacteria L-4 of South China Sea

The influence of secondary metabolites on the mix-cultivate marine bacteria and fungus were studied.The result indicated that bacteria obviously affected the secondary metabolites of fungus in the mix-cultivate,and even produce substances that were not found in the fungus or bacteria separately culture by TLC.Eight compounds were obtained from the fermentation broth of coral-derived bacteria L-4 in South China Sea.Their structures were determined to be cyclo(Trp-Ala)(1),cyclo(Gly-Tyr)(2),cyclo(Ala-Tyr)(3),and cyclo(Val-Tyr)(4),cyclo(Gly-Phe)(5),cyclo(Gly-Pro)(6),cyclo(Ala-Val)(7),and cyclo(Gly-Ala)(8) by spectroscopic analysis.The compounds 1,2,3,4,5,6,7,8 were all cyclo-dipeptides and first obtained from the marine coral-derived bacterium of South China Sea,which attributed to further research metabolism of mix-cultivation.