Tetradecylthioacetic acid reduces stenosis development after balloon angioplasty injury of rabbit iliac arteries.
2001
Abstract Background: tetradecylthioacetic acid (TTA) is a synthetic long-chain fatty acid analogue that inhibits the oxidative modification of low-density lipoprotein particles in vitro. We examined the influence of TTA on the arterial wall response after balloon angioplasty injury in a rabbit iliac model. Methods and results: 14 rabbits were randomized to receiving either TTA fatty acids 800 mg daily perorally (weight 3.6±0.1 kg) or to normal diet (weight 3.5±0.5 kg, P =NS). Angioplasty was performed via right carotidotomy on both iliac arteries using an oversized balloon catheter, the TTA group being pretreated for 3 weeks. After angioplasty, the lumen diameter was 2.37±0.18 versus 2.36±0.13 mm for the TTA and control groups, respectively ( P =NS). At 10 weeks follow-up angiography, minimal luminal diameter was 1.64±0.27 versus 1.13±0.52 mm for the TTA and control groups respectively ( P 0.05). Histomorphometry did not show significant differences in intimal hyperplasia between the two groups (maximal intimal thickness 0.22±0.04 versus 0.19±0.10 mm, P =NS and intimal area 0.32±0.12 versus 0.36±0.23 mm 2 , P =NS for the TTA and the control groups, respectively). In the heart, the sum of the n-3 fatty acids was 8.9±2.7 in the TTA group versus 4.3±0.2 mol% in the control group ( P P Conclusion: treatment with TTA is associated with positive arterial remodeling after angioplasty injury. The significance of the in vitro inhibition of human smooth muscle cell proliferation needs to be further elucidated.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
36
References
10
Citations
NaN
KQI