MetAP2 Inhibitor Treatment of High-Fat and -Fructose Fed Dogs: Impact on the Response to Oral Glucose Ingestion and a Hyperinsulinemic Hyperglycemic Clamp

We examined the methionine aminopeptidase 2 inhibitor fumagillin in dogs consuming a high fat- and fructose-diet (HFFD). In pilot studies (3 dogs that had consumed HFFD for 3yr), 8wk treatment with...