Low catalyst loadings for copper-catalyzed o-arylation of phenols with aryl and heteroaryl halides under mild conditions
2012
A practical and mild strategy has been developed for the cross-coupling
of O-arylation of phenol with differently substituted aryl halides
and heteroaryl iodides using low catalyst loading of copper iodide
under low operating temperature in DMF with TMHD as the ligand and
Cs2CO3 as the base. This method tolerates a
variety of functional groups including sterically hindered phenols and
heteroaryl iodides to afford products in good to excellent yields (up
to 95%).
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