Efficient diagnosis of Sjögren's syndrome to reduce the burden on patients

AbstractObjective. The purpose of this study was to investigate the procedures for efficiently diagnosing Sjogren's syndrome to reduce patient burden.Methods. This study analyzed data from 254 Japanese patients diagnosed with Sjogren's syndrome out of 4967 who visited our clinic complaining of xerostomia.Results. Of the 254 Sjogren's syndrome patients, 140 fulfilled the criteria proposed by the Committee on Sjogren's Syndrome of the Ministry of Health and Welfare of Japan, 228 fulfilled the criteria proposed by the American-European Consensus Group, and 69 fulfilled the criteria proposed by the American College of Rheumatology. Numbers of definitive cases varied with each set of criteria. Logistic regression analysis was used to analyze useful examination items for definitive diagnosis of Sjogren's syndrome, demonstrating that anti-Ro/SSA (odds ratio (OR), 7.165), lip biopsy (OR, 4.273), sialography (OR, 2.402), and ANA (OR, 0.678) correlated significantly with definitive diagnosis of Sjogren's syndrome.C...