SUBSTITUTED [1,2,4]TRIAZOLO[4,3-a]PYRIDINES, DEMONSTRATING PROPERTIES OF ANTAGONISTS OF ADENOSINE A2A RECEPTORS, AND THEIR APPLICATION

FIELD: chemistry. SUBSTANCE: in general formula A represents optionally substituted aminocarbonyl group -N-C(O)-, in which amino group can be substituted and substituents can be selected from hydrogen, C 1 -C 5 alkyl, possibly substituted with C 1 -C 3 alkoxy, C 3 -C 6 cycloalkyl, 5-6-membered heteroaryl, in which heteroatoms are selected from oxygen or nitrogen; aryl, selected from phenyl, possibly substituted with hydroxy, C 1 -C 5 alkyl, C 1 -C 5 alkoxy, halogen, C 1 -C 5 acylamino group, or naphthyl; or amino group is selected from C 3 -C 7 heterocyclyl, containing 1-2 heteroatoms in cycle, selected from nitrogen, oxygen or sulphur, possibly substituted with hydroxy, C 1 -C 3 alkyl, benzyl, phenyl, which can be substituted with halogen, and said heterocyclyl can be condensed with benzene ring; acylamino group, in which acyl is selected from C 1 -C 6 alkylcarbonyl, where alkyl can be substituted with phenyl, substituted with phenyl, in which substituents are selected from C 1 -C 5 alkoxy; 5-membered heteroaryl with heteroatom, selected from atom of oxygen or sulphur; benzoyl, possibly substituted with C 1 -C 5 alkyl, C 1 -C 5 alkoxy, C 1 -C 5 alkylthio or halogen, methylenedioxy; heterocyclylcarbonyl, in which heterocyclyl is selected from 5-6-membered heterocyclyl, with 1-2 heteroatoms, selected from nitrogen, oxygen or sulphur, possibly condensed with benzene ring and possibly substituted with C 1 -C 5 alkyl, halogen; or ureido group, in which one of substituents of terminal amido group represents hydrogen, and the second substituent is selected from: C 1 -C 3 alkyl, substituted with phenyl, 5-membered saturated or aromatic heterocyclyl, in which heteroatoms are selected from oxygen or sulphur; C 2 -C 6 alkenyl; aryl, selected from phenyl, substituted with C 1 -C 5 alkyl, C 1 -C 5 alkoxy, ethylenedioxy, methylenedioxy, halogen, C 1 -C 3 alkylcarbonyl; 5-membered heterocyclyl, in which heteroatoms are selected from sulphur or oxygen atom, and possibly substituted with alkyloxycarbonyl group; B represents non-aromatic cyclic substituent, selected from C 4 -C 6 cycloalkyl; and has other values, given in the invention formula. Values R1a R1b R1c are given in the invention formula. EFFECT: increased efficiency of application of compounds. 12 cl, 8 tbl, 13 ex