Enhancement of in vitro dissolution and pharmacodynamic potential of olanzapine using solid SNEDDS

The present research work focused on preparing a solidified lipidic self-nanoemulsifying drug delivery system (S-SNEDDS) by adsorbing liquid SNEDDS onto the surface of inert solid adsorbent (Aerosil-200) to improve the in vitro dissolution of poorly aqueous soluble drug, olanzapine and to evaluate their pharmacodynamic (Behavioral study) activity in Swiss albino mice. The liquid SNEDDS consisted of olanzapine, Acconon E and Cremophor EL. The powder flow properties were characterized using parameters viz. angle of repose (θ), Haussner’s ratio and Carr’s index. S-SNEDDS demonstrated good flow characteristics. The solid-state characterizations of S-SNEDDS by fourier transform infrared spectroscopy, differential scanning calorimeter and powder X-ray diffraction studies confirmed the amorphous behavior of olanzapine in the S-SNEDDS. Enhanced in vitro drug release and pharmacodynamic efficacy were attained from solidified-SNEDDS in comparison to olanzapine powder signifying the immense potential offered by S-SNEDDS and it could be a better alternative for oral administration of olanzapine.