Mammary Cancer Bone Metastasis Follow-up Using Multimodal Small-Animal MR and PET Imaging

compared in terms of the magnitude of change in their uptake and variability. We observed that 11 C-methionine SUVmean variations in the tumor were more important than those of 18F-FDG. We also found fewer interindividual variations using SUVmean as a quantitative parameter than SUVmax. Conclusion: This preclinical evaluation demonstrated that a PET/MR image coregistration protocol provided a powerful tool to evaluate bone tumor progression in a rat model of bone metastasis and that this protocol could be translated to improve the clinical outcome for metastatic breast cancer management.