Analysis of the first CD4+ T lymphocytes counts test in sero-conversion of 116 cases with HIV antibody indeterminate

Objective To understand the immune status and disease progression by analyzing the first CD4+ T lymphocytes counts (CD4 cells), and to provide the basis for the follow-up and intervention of HIV antibody indeterminate results which turn positive at later detection. Methods From January 2010 to April 2017, the first test concerning CD4 cells and related factors of 116 sero-conversion cases with HIV antibody indeterminate in Harbin were retrospectively analyzed. Results All 116 subjects show the average age of(35.80±9.64) years old with the youngest at 16 years old.Men accounted for 92.2% (107/116), unmarried 72.4% (84/116).49.1% (57/116) have college or higher than college education background.The first tested CD4 cells averaged at(429.03±181.61)/μL, with a minimum 44 /μL.CD4 cells < 500 /μL accounted for 65.1% (82/116). Only 29.3% individuals were obcerued to have(34/116) WB reinspection and CD4 cell detection in time. Conclusion Sero-conversion of 116 cases with HIV antibody indeterminate has entered an abnormal immune status with various levels of immunosuppression.Follow-up for peoples with HIV antibody indeterminate test result is important.They must be informed to have re-inspection, or to increase the frequency of re-inspection.In some cases, nucleic acid detection is required during the window period of HIV infection.More importantly, CD4 cell detection must be performed in time for sero-conversion cases with HIV antibody inderteminate test results.At the same time, the medical consultation should be improved to effectively prevent HIV infection. Key words: Human immunodeficiency virus; Sero-conversion with HIV antibody indeterminate; CD4+ T lymphocytes