The study of antiepileptic activity of clove oil by MES model in mice

Background: The objective was to evaluate and compare the effect of extract of essential oil of clove with the standard sodium valproate on MES model. Methods: A total of thirty mice were taken, they were given an electroconvulsive shock. Thirty mice were divided into five groups of six animals each, the control group received distilled water 5ml/kg i.p, standard received Inj. Sodium valproate 200 mg/kg i.p. another group received Sesame oil – 10ml/kg i.p(control), test groups received Clove oil- 0.075 ml/kg i.p., Clove oil-0.1ml/kg i.p respectively. All the injections were given 30 minutes before the test. Results: Clove oil produced significant antiepileptic effect at all the doses. Conclusion: Clove oil has shown significant antiepileptic activity in mice. Keywords: Epilepsy, Clove oil, Albino mice, MES model