In vitro characterization of hepatic flavopiridol metabolism using human liver microsomes and recombinant UGT enzymes.
2002
Purpose. To assess the contribution of drug metabolism to the variability on flavopiridol glucuronidation observed in cancer patients, and to determine the ability of all known human UDP-glucuronosyltransferase (UGT) isoforms to glucuronidate flavopiridol.
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