Chiral Broensted Acid Catalyzed Enantioselective Friedel—Crafts Reaction of 4,7‐Dihydroindoles with Trifluoromethyl Ketones.
2011
In the presence of a chiral phosphoric acid, reaction of substrates (I) with aromatic trifluoromethyl ketones (II) and ethyl 4,4,4-trifluoroacetoacetate (V) gives 2-substituted 4,7-dihydroindoles with a trifluoromethylated tertiary alcohol moiety.
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