Clinical study of reducing the inflammatory response in deep partial thickness skin burns under the treatment of xenogeneic (porcine) acellular dermal matrix

Objective To discuss the mechanism of xenogenic(porcine) acellular dermal matrix (ADM) alleviating the inflammatory reaction in the process of treating deep partial thickness skin burn injury. Methods Seventy deep partial thickness skin burn injury patients were chosen and randomly divided into two groups. The patients in experimental group were treated with ADM while other patients were treated with povidone iodine ointment in control group. To regard the day of hospital admission as the 1st day after injury, The levels of tumor necrosis factor-alpha(TNF-α), interleukin-1beta, interleukin-6 and interleukin-10 were detected on the 1st, 3rd, 7th and 10th day post burn at all the patients and the change of patients′ vital signs as well as peripheral blood leukocyte count were monitored. SPSS 13.0 statistical software was used to process the data. Multiple comparision between groups was made using the Student-Newman-Keuls methods. Results The serum TNF-α level of patients in the experimental group was(1.55±0.62) ng/mL, which was lower than that of patients in the control group on the 3rd day post burn, the difference was statistically significant (P<0.05). In addition, the vital signs and peripheral blood leukocyte count of patients in experimental group returned to normal more quickly than that of patients in the control group. However, There were no significant differences in serum levels of interleukin-1beta, interleukin-6 and interleukin-10 between the two groups at different times post burn(P values were less than 0.05). Conclusions Through lowering the level of serum TNF-α of patients, ADM is able to alleviate the postburn systemic inflammatory response syndrome and reduce the occurrence of severe complications. Key words: Burns; Systemic inflammatory response syndrome; Cytokines; Xenogeneic(porcine) acellular dermal matrix