PROTEIN CHIMERIZATION: A NEW FRONTIER FOR ENGINEERING PROTEIN THERAPEUTICS WITH IMPROVED PHARMACOKINETICS

With the advancement of medicine, the utility of proteins therapeutic is increasing exponentially. However, a significant number of protein therapeutics suffer from grave limitations, which includes their subpar pharmacokinetics. Here, we have reviewed the emerging field of protein chimerization for improving the short circulatory half-life of protein therapeutics. We have discussed various aspects of protein therapeutics aiming at their mechanism of clearance, and various approaches utilized to increase their short circulatory half-life with principle focus on the concept of chimerization. Furthermore, we have comprehensively reviewed various components of chimera, such as half-life extension partners and linkers; their shortcomings, and prospective work to be undertaken for developing effective chimeric protein therapeutics. SIGNIFICANCE STATEMENT Not applicable