Phase III Trial Comparing 4-Day Chronomodulated Therapy Versus 2-Day Conventional Delivery of Fluorouracil, Leucovorin, and Oxaliplatin As First-Line Chemotherapy of Metastatic Colorectal Cancer: The European Organisation for Research and Treatment of Cancer Chronotherapy Group

Sylvie Giacchetti,Georg A. Bjarnason,C. Garufi,Dominique Genet,Stefano Iacobelli,Marco Tampellini,Rune Smaaland,C. Focan,B. Coudert,Yves Humblet,Jean Luc Canon,A. Adenis,Giovanni Lo Re,Carlos Carvalho,Johannes Schueller,Nicole Anciaux,Marie Ange Lentz,B. Baron,Thierry Gorlia,Francis Lévi

Phase III Trial Comparing 4-Day Chronomodulated Therapy Versus 2-Day Conventional Delivery of Fluorouracil, Leucovorin, and Oxaliplatin As First-Line Chemotherapy of Metastatic Colorectal Cancer: The European Organisation for Research and Treatment of Cancer Chronotherapy Group

2006

Purpose In two previous randomized trials, the adjustment of chemotherapy delivery to circadian rhythms improved tolerability and anticancer activity compared with constant-rate infusion during 5 days in patients with metastatic colorectal cancer.

Keywords:

Fluorouracil
Cancer
Metastasis
Colorectal cancer
Pathology
Medicine
Oxaliplatin
Tolerability
Chemotherapy
Antimetabolite

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