Acute severe Autoimmune Hepatitis with anti-Rods and Rings autoantibodies: Literature first evidence.

Autoimmune hepatitis (AIH) was defined as a progressive, chronic inflammatory autoimmune liver disease (ALD). The diagnosis of AIH requires the presence of characteristic clinical and laboratory features, and the exclusion of other clinical conditions that cause chronic hepatitis and cirrhosis. AIH can have an acute onset that mimics an acute viral or toxic hepatitis or an acute severe (fulminant, ASF) presentation that satisfies criteria for acute liver. Guidelines from the european Association for the Study of Liver Diseases define ALF with absence of pre-existing liver disease, acute onset of ? 26 weeks, coagulopathy (international normalised ratio (INR) ? 1.5) and presence of hepatic encephalopathy (HE). In recent years, autoantibodies (Aab) targeting subcellular structures described as the rods and rings (R&R) pattern in HEp-2 ANA have been presented as a unique and particular case of Aab generation. These R&R structures are composed of inosine monophosphate dehydrogenase type 2 (IMPDH2), and their formation can be induced in vitro by several small-molecule inhibitors. Aab targeting these relatively unknown structures have been observed in hepatitis C virus (HCV) patients who have undergone treatment with pegylated interferona/ ibavirin (IFN/RBV) therapy. Now We present and characterized a case patient with  R&R and SMA Aab in AIH (ASF, fatal, without liver trasnplantation). For our knowledge this is the first evidence described in the Literature.Our early experience showed the R&R circulating Aab in one patient with Primary biliary cholangitis (PBC). This work now demonstrate that R&R Aab can be also present in AIH case.