Use of 99mTc-MIBI scintigraphy in the evaluation of the response to chemotherapy for osteosarcoma: comparison with 201Tl scintigraphy and angiography

Background In the treatment of osteosarcoma, the chemotherapeutic effect influences decisions regarding the surgical margin, continuation of chemotherapy, and choice of anticancer drugs for further chemotherapy. Therefore, it is necessary to evaluate the response to chemotherapy in the middle of the chemotherapy course. In this study, we investigated the use of 99mTc-hexakis-2-methoxyisobutyl-isonitrile (99mTc-MIBI) scintigraphy in evaluating the response to chemotherapy of patients with osteosarcoma in comparison with 201Tl scintigraphy and angiography.