Childhood Bullous Pemphigoid: A Case Report and Literature Review

Bullous pemphigoid is a very rare dermatologic disorder in children. We report a 1-year and 9-month-old boy, who was diagnosed childhood bullous pemphigoid on the basis of clinical findings and confirmed by skin biopsy showing subepidermal blisters with dermal layer infiltrated with neutrophils, a unique histological finding. The result mimicked the histological findings of linear immunoglobulin A bullous disease. Direct immunofluorescence showed linear deposits of IgG and C3 at dermal-epidermal junction, similar to epidermolysis bullosa acquisita and bullous systemic lupus erythematosus. We suggested the differential diagnosis of subepidermal blisters should include linear immunoglobulin A bullous disease of childhood, epidermolysis bullosa acquisita and bullous systemic lupus erythematosus.