Study on preparation and release of mitoxantrone transfersomes in vitro

OBJECTIVE To prepare the mitoxantrone transforsomes with efficient encapsulation and explore sustained-release characters of transfcrsomes. METHODS The mitoxantrone transforsomes were prepared by film dispersion. The particle size, particle distribution and Z-potential of colloid solution were obtained by laser scatterometer. The encapsulation efficiency was measured by sephadex gel filtration. The release of mitoxantrone transforsomes were recorded in vitro.RESULTS The mean diameter of mitoxantrone transformes was 32.5 nm. The encapsulation efficiency of mitoxantrone was 100% . The cumulative release of the mitoxantrone transformes in PBS(7.4) was 39.7% in 312 h. The release profile in vitro was fitted well with a zero-order equation. CONCLUSION The mitoxantrone transforsomes showed an efficient encapsulation and an obvious sustained release character.