Observation of curative effect on mifepristone combined with methotrexate in the treatment of patients with ectopic pregnancy

Objective To explore the effectiveness of mifepristone combined with methotrexate in the treatment of ectopic pregnancy.Methods Selected 52 patients with ectopic pregnancy sought treatment in our hospital from october 2011 to september 2012.They were assigned randomly into two groups(there were 25 cases in treated group,and 27 cases in control group) with the help of random digital table.The treated group used mifepristone combined with methotrexate,while the control group used methotrexate only.Observed the recuperative time of blood β-HCG,the time progesterone value dropped below 5 ng/mL,disappearance time of vaginal bleeding,mass and abdominal pain.Results The recuperative time of blood β-HCG,the time progesterone value dropped below 5 ng/mL,and the disappearance time of vaginal bleeding,mass and abdominal pain of treated group were shorter than that of control group(P 0.05).Conclusion Mifepristone combined with methotrexate in the treatment of ectopic pregnancy decreases blood β-HCG and progesterone value quickly,and the disappearance time of vaginal bleeding,mass and abdominal pain is shorter than the single use of methotrexate.Drug combination has a lower incidence of adverse events than single use of methotrexate.Statistically significant difference was found in the incidence of adverse events between two groups.So it worth clinical application.