Peptide 961) Synthese einiger [2-(p-Biphenylyl)isopropyloxycarbonyl]-Aminosäurederivate
1975
Die Darstellung der N-[2-(p-Biphenylyl)isopropyloxycarbonyl]-Derivate (Bpoc-Derivate) des Cysteins unter Verwendung der Thiolschutzgruppen Tetrahydropyranyl (Thp) fur 1, Diphenylmethyl (Dpm) fur 2, Trityl (Trt) fur 3 und S-tert.-Butyl (SBut) fur 4 sowie die Synthese von aktivierten Estern der Bpoc-Derivate des Glycins (5), Isoleucins (6) und Prolins (7) werden beschrieben. An einem Beispiel wird die Moglichkeit aufgezeigt, die Bpoc-Gruppe uber das Bpoc-Azid nachtraglich in den Peptidverband einzufuhren.
Peptides 961). — Synthesis of Some 2-(p-Biphenylyl)isopropyloxycarbonyl Amino Acid Derivatives
The synthesis of N-[2-(p-biphenylyl)isopropyloxycarbonyl]cysteinyl derivatives with the four different thiolprotecting groups tetrahydropyranyl (Thp) for 1, diphenylmethy1 (Dpm) for 2, trityl (Trt) for 3, and S-tert.-butyl (SBut) for 4 as well as the preparation of the activated esters of the Bpoc derivatives of glycine (5), isoleucine (6), and proline (7) are described. As it is demonstrated in one case Bpoc-azide reacts with the free amino function of peptides yielding the correspondent Bpoc-protected peptide derivative.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
26
References
8
Citations
NaN
KQI