Spirulina platensis supplementation, macrophage inhibitory cytokine-1 (MIC-1), oxidative stress markers and anthropometric features in obese individuals: A randomized controlled trial

Abstract Backgrounds Obesity is associated with numerous chronic diseases. The current study was aimed at investigating the effects of Spirulina platensis on Macrophage inhibitory cytokine 1 (MIC-1), biomarkers of oxidative stress and anthropometric features in obese patients. Methods Fifty six obese individuals, aged between 20–50 years old, participated in the current trial and were randomly allocated into two groups of intervention and control receiving either Spirulina platensis or a placebo daily for 12 weeks, respectively. Changes in serum and blood concentrations of MIC-1, markers of oxidative stress and anthropometric features were evaluated at baseline and after the intervention period. Appetite was also measured by visual analogue scale (VAS). Results Spirulina platensis treatment for 12 weeks significantly reduced MIC-1 concentrations and appetite in obese individuals (P  Conclusion Considering the beneficial therapeutic effects of Spirulina platensis in attenuating anthropometric parameters and reducing oxidative stress, it can be suggested as a complementary therapeutic approach to obesity and related disorders.