Diagnostic accuracy of flow-mediated dilatation and intima-media thickness for the presence of significant coronary artery disease

Abstract Our purpose was to determine and compare the diagnostic accuracy of flow-mediated dilatation (FMD) and intima-media thickness (IMT). Included were 543 patients. FMD was performed in 543 patients, IMT in 233, and coronary arteriography (CAG) in 442. Analyzing ROC (receiver operating characteristic) curves, FMD ≤5.64% showed 89% sensitivity, 62% specificity, 65% positive predictive value (PPV), and 88% negative predictive value (NPV) for the presence of angiographically significant coronary artery disease (CAD). IMT ≥0.788 mm had 71% sensitivity, 62% specificity, PPV 60%, and NPV 73% for the presence of advanced coronary atherosclerosis. FMD >8% or IMT