Reserpine処置Ratの肝臓Glycogen量および血糖量に対する各種薬剤の影響 ―MAOI，5HTP，DOPA，ACTHおよびCortisoneの併用効果―

Present study was undertaken to determine whether distress with reserpine is protected with chronic administration of central acting drugs (MAOI, 5HTP and DOPA) and adaptation hormones (ACTH and cortison)Methods and materials: Male rats of wistar strain, weighing 70-90 g, were maintained on high sucrose diet and 5 % sugar solution near for 30 days. Rats were intramuscularly injected with physiological saline solution (2.5 ml/kg) as control animals, with reserpine (1.25 mg/kg) to induce distressed state, with isocarboxazide (MAOI, 2.0 mg/kg), 5HTP(2.0 mg/kg) and DOPA (100 mg/kg) to produce serotonergic or/and adrenergic state, with ACTH (5 mg/kg) or cortison (20 mg/kg) to activate homeostatic state and in combination with reserpine and MAOI, 5HTP, DOPA, ACTH or cortison to observe the antagonism or interaction between reserpine and other drugs, every other day, for this period. Blood sugar determined spectrophotometrically by method of Asator-King and liver glycogen extracted as described by Fujii and finally determined by Asator-King methodwere measured as the indicator on the degree of defensive reactions.The results are summed up as follows: 1) Hypoglycogenesis of rat liver by reserpine was inhibited in combined administration with MAOI or cortison, but accelerated further with 5HTP, DOPA or ACTH, while the independent administration of MAOI, 5HTP, DOPA or each hormones (ACTH and cortison) produced the hyperglycogenesis. 2) Reserpine-hyperglycemia was further enhanced in combination with MAOI, DOPA or ACTH, but not with 5HTP or cortison, while hyperglycemia was produced in rats treated independently with MAOI or cortison but not with 5HTP, DOPA or ACTH.