Использование углеродных сорбентов при критических состояниях организма

At the first stage of the study, 58 patients after surgical removal of abdominal cavity tumors are examined and treated. In 28 patients, the postoperative period is complicated with diffuse purulent peritonitis. So, the complex therapy of these patients is supplemented with 1 2 hemosorption sessions using a VNIITU-1 carbon sorbent in a sterile saline solution. The sorbent, which is awarded with a gold medal of the International Salon of Innovations and Investments, has a mesoporous surface that allows toxic substances of low and moderate molecular weight to be removed from the human body. The hemosorption sessions substantially reduces haematological, immunological and biochemical disorders and ultimately decreases mortality in the early postoperative period by a factor of 3.7. The second stage of the study was aimed to develop a molded carbon sorbent based on VNIITU-1 for selective sorption of proinflammatory cytokines form blood plasma. Bench testing is performed with blood plasma obtained during plasmapheresis from 15 patients with acute pancreatitis complicated with pancreonecrosis and diffuse purulent peritonitis. The TNF-a, IL-1 p, IL-4, and IgA contents are determined in blood plasma before and after the sorption. The modified hemosorbent VNIITU-1-PVP showes much higher sorption capacity and selectivity than the initial VNIITU-1. This concerns proinflammatory cytokine interleukin-1B: its concentration decreases by a factor of 33.5 and TNF-a was virtually absent. The level of antiinflammatory cytokine interleukin-4 is nearly twofold higher as compared to blood plasma that was passed through VNIITU-1. The IgA content remained virtually unchanged.