AUGMENTATION OF MITOCHONDRIAL ATP-SENSITIVE K+ CHANNEL OPENING FOLLOWING LONG-TERM THERAPY WITH BENDAVIA (MTP-131) IN DOGS WITH ADVANCED HEART FAILURE

Reduced nicotinamide adenine dinucleotide phosphate (NADPH) level is increased in the failing heart and leads to reduced opening of the mitochondria ATP-dependent K+ channels (MitoKATP) leading to ionic dysregulation in the mitochondrial environment with subsequent matrix contraction and reduced ATP