ALKYLATION OF 5-SUBSTITUTED TETRAZOLES WITH MANNICH BASES

Mixtures of N(1) and N(2) isomers are formed in the alkylation of 1H-5-R-tetrazoles with N-(2-hydroxy-3-methoxy-5-formylbenzyl)piperidine, whereas primarily one of two possible N(1) or N(2) isomers is formed in the case of alkylation with N-(3,5-di-methyl-4-hydroxybenzyl)piperidine, depending on substituent R.