Therapeutic Effect of Intensive Insulin Therapy on Critical Hyperglycemia Cases with Different Traditional Chinese Medical Syndromes

Objective:To investigate the relationship of curative effect of intensive insulin therapy with traditional Chinese medical syndromes and interleukin 6(IL-6) levels in critical hyperglycemia cases.Methods:The critical hyperglycemia cases with APACHE II scores were allocated randomly to two groups.Thirty patients with 4.4～6.1mmol/L blood glucose were enrolled in treatment group and received intensive insulin therapy,and 20 cases with 10.0～11.1mmol/L blood glucose were enrolled in control group and received conventional therapy.Serum IL-6 level was detected by ELISA before treatment,and on day 1,5 and 10 after treatment.The relation of syndrome patterns with mortality and IL-6 level was investigated.Results:On day 1,5 and 10 after treatment,serum IL-6 expression level in the treatment group was lower than that in the control group(P0.05).Serum IL-6 expression level in both group after treatment differed from that before treatment(P0.01).The difference of IL-6 level in excessive heat syndrome and qi stagnation and blood stasis syndrome was significant(P0.05 compared with the other syndromes).Excessive heat syndrome had the lowest IL-6 level,and qi stagnation and blood stasis syndrome had the highest IL-6 level.In the treatment group,death occurred in one patient with qi stagnation and blood stasis syndrome,and in one patient with fu-organ qi obstruction syndrome.In the control group,death occurred in two patients with qi stagnation and blood stasis syndrome,in one patient with fu-organ qi obstruction syndrome,and in one patient with syncope-collapse syndrome.Conclusion:The curative effect of intensive insulin therapy on critical hyperglycemia cases is correlated with their syndrome patterns and serum IL-6 level.