C-反应蛋白及其－717A/G多态性与心房颤动的相关性

Objective: To investigate the relationship between C-reactive protein (CRP) and its-717A/G polymorphism in atrial fibrillation (AF) of the population of the city of Nantong. Methods: The relationships between AF and AF risk factors were analyzed by comparing genders, ages and body mass index (BWI) in 92 AF patients and 60 non-AF control subjects. The serum CRP levels were detected by immunoturbidimetry in of the two groups. The CRP-717A/G polymorphism was detected by polymerase chain reaction-restriction fragment-length polymorphism in patients and control subjects. Results: The serum CRP level was positively correlated with the left atrium internal diameter (LAD) in AF patient group (r=0.58, P＜0.01). The level of CRP was significantly higher in AF patient group compared with that of control group (P＜0.01). The serum CRP level was higher in patients with non-paroxysmal atrial fibrillation than that of patients with paroxysmal atrial fibrillation (P＜0.05). There was no significant difference in the frequency of CRP genotype between AF and control groups (P＞0.05). But the alleles frequency of the G was lower in AF group than that of control group (P＜0.05). Conclusion: The serum CRP level is associated with AF and its subgroups. The serum CRP level is positively correlated with LAD. The results suggest that the inflammation influences the AF though atrium reconstruction. The relationship between CRP-717A/G and AF still needs further large-scale perspective studies.