Solubility of Aspartame in Water, Methanol, Ethanol and Different Binary Mixtures in the Temperature Range of (278.15 to 333.15) K

The solubility of aspartame in water, methanol, ethanol, and their binary mixtures (methanol + water and ethanol + water) was measured in the temperature range from 278.15 K to 333.15 K under atmospheric pressure. The results indicate that the solubility of aspartame in the selected solvents increases with increasing temperature and is higher in water than in pure alcohols. However, the solubility is higher in the binary mixtures than in water and it increases with an increase of the mass fraction of alcohols. The experimental data were correlated by the modified Apelblat model, and thus calculated values are in good agreement with the experimental data in the temperature range studied. The enthalpy and entropy of solution were evaluated using the van’t Hoff equation. The dissolution enthalpy and entropy of aspartame in pure solvents predicted from the solubility data are less than that in mixed solvents.