Novel silicon phthalocyanines axially modified by morpholine: Synthesis, complexation with serum protein and in vitro photodynamic activity
2006
Abstract Two novel morpholine-containing silicon (IV) phthalocyanines, namely bis (2-morpholine) ethoxy phthalocyaninatosilicon ( 2 ) and bis (2-( N -methyl-morpholine)) ethoxy phthalocyaninatosilicon diiodide ( 3 ), have been prepared. The complexations of these two compounds with three serum proteins including the bovine serum albumin, human serum albumin, and transferrin have also been investigated. The non-aggregated compound 3 exhibits a high photodynamic activity towards B16 melanoma tumour cells with an IC 50 value of 0.30 μM.
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