Predicting Cognitive Decline in Subjects at Risk for Alzheimer Disease by Using Combined Cerebrospinal Fluid, MR Imaging, and PET Biomarkers

A model combining clinical information with MR imaging, fluorine 18 fluorodeoxyglucose (FDG) PET, and cerebrospinal fluid markers yielded the highest accuracy for predicting future mild cognitive impairment conversion; however, the most efficient model included only FDG PET with the clinical covariates.