Codominant nature of alleles of locus E2 controlling synthesis of human blood serum cholinesterase

The C5 component of ChE2 (locus E2) of human serum is not an autosomal dominant trait. This component is a part of the group of isozymes C5-10 which can be detected by polyacrylamide gel electrophoresis in acid medium (pH 4.8). The new electrophoretic data show that polymorphism of ChE2 is determined rather by a pair of autosomal codominant alleles called ChE2A and ChE2B. Serum of subjects with phenotypes ChE2AB (C5+) and ChE2BB (C5-) shows the same level of cholinesterase activity on the average.