The First Stereospecific Synthesis of Michellamine B.

The dimeric alkaloid michellamine B is synthesized streospecifically by the palladium-catalysed cross-coupling of the 6′-naphthaleneboronic acid of the tetrabenzylated derivative of korupensmine A and the 6′-bromo analogue of the tetrabenzylated derivative of korupensmine B, both of which are prepared by total synthesis.