Effect of prostaglandin E2 on ATP-induced Ca2+ responses in human THP-1 monocytic cells.

To clarify the relation between ATP and prostaglandin E2 (PGE2) in the immunologic system, we investigated the acute and chronic effects of PGE2 on activation of purinergic signaling in monocytes by measuring the ATP-induced elevation of intracellular Ca2+([Ca]i) in fura-2-loaded THP-1 monocytes.