Anticoagulation medical device, and preparation method thereof

The invention discloses an anticoagulation medical device, and a preparation method thereof. The preparation method comprises following steps: a, a device main body of the anticoagulation medical device is prepared; and b, the surface of the device main body is coated with a positively charged polyelectrolyte and a negatively charged polyelectrolyte via alternate adsorption so as to form a coating layer and obtain the anticoagulation medical device. The preparation method also comprises a step of crosslinking of the positively charged polyelectrolyte with the negatively charged polyelectrolyte using a cross-linking agent. The preparation method is simple; preparation can be realized using a simple solution circulating device; a stable coating structure can be obtained via crosslinking; preparation can be carried out at mild aqueous environment; no toxic solvent is used; the preparation method is friendly to the environment; no special requirement on the shape structure of the anticoagulation medical device is required by the preparation method; and preparation can be realized on the surfaces of a plurality of medical devices with complex structures.