ALCOHOLIC LIVER DISEASE (ALD); IMPLICATION OF OXIDATIVE STRESS & EXTRAPOLATIVE FACTORS IN PATIENTS SUFFERING, UPDATE FROM LOCAL POPULATION OF PUNJAB-PAKISTAN

Objective: The aim of the present study was to investigate the changes in biochemical parameters including lipid profile, liver and kidney profile as well as oxidative stress profile, particularly in patients suffering from alcoholic liver disease (ALD). Study design: Fifty chronic alcoholics admitted for treatment to the in-patient wards at Jinnah Hospital, Lahore- Pakistan. Chronic alcoholics with alcohol abuse for more than four to five years, and with or without clinical complications, were included. Apparently twenty healthy individuals served as control. Period: 2012-2013. Materials and methods: Various circulating biochemical biomarkers including renal profile, hepatic and lipid profile were evaluated. Moreover, stress markers (MDA. SOD, GSH and catalase) were also investigated. Results: A very strong direct and indirect correlation of ALP was found with TB, MDA and GSH (r=.950**, r=.929** and r=- .967** respectively, P<0.01). MDA was observed having very strong indirect correlation with GSH and catalase (r=-.909** and r=-.777** respectively, P<0.01). Conclusion: All parameters in combinations may be useful indicator or may be good and reliable biochemical markers for identification and determination of severity of alcoholic liver diseases (ALD). The damaging of hepatocytes due to the consumption of alcohol disturbs almost all types of biochemical coordination in the biological system.