Reconstructable Uterus-Derived Materials for Uterus Recovery towards Efficient Live Births

Uterine factor infertility is increasingly common in modern society and has severely affected human life and health. However, the existing biomaterial scaffold-mediated system remains limited in efficiently uterus recovery, leading to low pregnancy rate and live birth. Here, we demonstrate a reconstructable uterus-derived materials (RUMs) by combing with uterus-derived extracellular matrix (ECM) and seeded chorionic villi mesenchymal stem cells (MSCs) for uterus recovery, achieving highly efficient live births in rats with severe uterine injury. The RUMs can be designed into different states (such as liquid RUMs and solid RUMs) and shapes (such as cuboid, triangular-prism and cube) in terms of requirements. The RUMs can effectively prevent intrauterine adhesion, and promote endometrial regeneration and muscle collagen reconstruction as well as accelerate wound healing by constructing physical barrier and secreting cytokines, allowing efficient uterus recovery. The injured uterus nearly achieves complete regeneration after treating with our RUMs and has normal pregnancies for supporting fetal development and live births, similar to the normal rats. Our study provides a regenerative medicine therapeutics for uterine factor infertility. This article is protected by copyright. All rights reserved.