The comparative pattern of neuromidin and magnetic stimulation influence on neuroplasticity in experimental traumatic neuropathy

OBJECTIVE: Traumatic neuropathies are among the most actual problems in neurology due to the severe neurological deficit in most cases and poor prognosis of recovery. We evaluated the effect of ipidacrin (cholinesterase inhibitor) and magnetic stimulation on neuroplastic axonal changes after experimental neurotmesis of rat's sciatic nerve. MATERIAL AND METHODS: Animals (20 rats) were stratified into 3 groups. There was no treatment in the control group; in the second -group experimental animals underwent 3-5 min daily rhythmic magnetic stimulation (0,8-1T, 3 Hz) The third group of animals received intramuscular 0,035 mg of ipidacrin daily within 1 month. RESULTS AND CONCLUSIONS: Based on the received data on the restoration of myelin, axons, myelin nodes structure and lemmocyte ultrastructure), we have concluded that both magnetic stimulation and ipidacrin can trigger restorative and compensative processes in traumatic neuropathies.