ВЛИЯНИЕ ОСТРЫХ ОТРАВЛЕНИЙ ПСИХО- ФАРМАКОЛОГИЧЕСКИМИ ПРЕПАРАТАМИ НА НЕКОТОРЫЕ ПОКАЗАТЕЛИ НЕЙРОЭНДОКРИННОЙ СИСТЕМЫ У ДЕТЕЙ И ВЗРОСЛЫХ

The stress-realizing reaction provides a metabolic basis of compensatory and adaptive changes occurring in the human body under the impact of aggressive factors including chemical agents. The main role in neuroendocrine regulation of a stress is played by the brain layer of adrenal glands. The thyroid gland, as well as adrenal glands also belongs to «classical» endocrine glands and plays an important role in maintenance of homeostasis. Researches were conducted in 144 patients aged from 20 to 45, in 40 children at the age of 11 to 15 and in 45 patients from 1 to 5 year old admitted to hospital before a special care was performed. The conducted researches showed that during the first hours after acute poisonings with psychopharmacological preparations, irrespective of age, cortisol concentration increased in patients blood proportionally to the severity of intoxication which was more expressed in children at early age. Concentration changes in the thyroid gland hormones in all patients happened within reference values.