Three Unusual New Sesquiterpenes from Alpinia oxyphylla

Two new norcadinene sesquiterpenes oxyphyllones C and 1) (1 and 2, rest).), and one new 1,10-secoguaiane sesquiterpene, (+)-mandassidion (3), together with two known compounds. oxyphyllenodiol B (4) and (1R,2R)-p-menth-3-ene-1,2-diol (5), were isolated front the fruits of Alpinia oxyphylla. Their structures were determined on the basis of spectroscopic analysis, including 2D-NMR spectroscopic techniques. Compounds 1, 2, and 3 exhibited no cytotoxicity against three cancer cell lines.